Association of Protein Tyrosine Phosphatase 1B Gene Polymorphisms With Type 2 Diabetes
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چکیده
منابع مشابه
Brief Genetics Report Association of Protein Tyrosine Phosphatase 1B Gene Polymorphisms With Type 2 Diabetes
The PTPN1 gene codes for protein tyrosine phosphatase 1B (PTP1B) (EC 3.1.3.48), which negatively regulates insulin signaling by dephosphorylating the phosphotyrosine residues of the insulin receptor kinase activation segment. PTPN1 is located in 20q13, a genomic region linked to type 2 diabetes in multiple genetic studies. Surveys of the gene have previously identified only a few uncommon codin...
متن کاملAssociation testing of the protein tyrosine phosphatase 1B gene (PTPN1) with type 2 diabetes in 7,883 people.
Protein tyrosine phosphatase (PTP)-1B, encoded by the PTPN1 gene, inactivates the insulin signal transduction cascade by dephosphorylating phosphotyrosine residues in insulin signaling molecules. Due to its chromosomal location under a chromosome 20 linkage peak and the metabolic effects of its absence in knockout mice, it is a candidate gene for type 2 diabetes. Recent studies have associated ...
متن کاملPolymorphisms within the protein tyrosine phosphatase 1B (PTPN1) gene promoter: functional characterization and association with type 2 diabetes and related metabolic traits.
BACKGROUND Protein tyrosine phosphatase 1B (PTPN1) dephosphorylates insulin receptors and attenuates insulin signaling. Polymorphisms in the coding sequence of PTPN1 have been variably associated with type 2 diabetes (T2D). We hypothesized that variations within the PTPN1 promoter might contribute to the development of T2D and related metabolic traits. METHODS We screened 2.0 kb of PTPN1 prom...
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English version of this article has been published in “ journal of diabetes & metabolic disorders “ with both editor-in-chiefs agreement; aims to be available for Persian language readers; http://doi.org/10.1111/j.1399-039.2007.00956.x.
متن کاملType 2 Diabetes Mellitus and Protein-Tyrosine Phosphatase 1B1
Diabetes is a common metabolic disease which characterized by hyperglycemia, mainly divided into type 1 diabetes mellitus and type 2 diabetes mellitus. Insulin-dependent type 1 diabetes mostly resulted from the damage of pancreatic β cells which makes the absolute lack of insulin; Type 2 diabetes, which insulin independent, the mainly initial factors are insulin resistance (IR) and the relative...
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ژورنال
عنوان ژورنال: Diabetes
سال: 2004
ISSN: 0012-1797,1939-327X
DOI: 10.2337/diabetes.53.11.3007